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Using two separate drugs to lose weight can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the those who go through it you need to err along the side of caution and let the FDA do its job and demand some investigation be done so the public is aware of the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies are in business to generate income and that they would say almost anything to keep people on their own medications. Researchers discovered that participants using this drug to get a year, dropped a few pounds within one month and have kept the body weight off through the entire 56 weeks of the study. Contrave is a combination from the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which can be made up of many active ingredient, which might make them more potent and safer. Combo-pilling could be the newest fad or in addition to this the newest into the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular is the fact that by right now there are not any long term prescription weight loss supplements that have been licensed by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be authorized by the FDA. Seizures are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug may also raise blood pressure level and heartbeat, and mustn't be used in people who have a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise hypertension and heartrate and must stop used in patients with uncontrolled high hypertension, along with by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients with a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients to the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking. "This could be the first drug I'm conscious of that targets both appetite and reward centres in the brain," he explained.

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